"Research science can be corrupted at any step of the research process. It is the very reason behind the passion that drives the arguments for full disclosure and transparency. Since this is not a theoretical exercise, but one from which human lives are held in the balance, the stages of the process are worth reiterating: If basic science is corrupted, clinical protocols can not accurately proceed. If the results of an early clinical trial are misreported, the basis for larger trials is skewed. If negative data or adverse effects are hidden, the risk -benefit questions cannot be addressed. If the positive conclusions are embellished, the marketing and advertisement are at risk. If the regulatory bodies do not perform their tasks in an independent and unbiased manner, the approval process is corrupted"